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Why will cerebral edema occur while correcting diabetic ketoacidosis (DKA)?

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Why will the rapid correction of hyperglycemia in DKA cause cerebral edema?

While managing diabetic ketoacidosis, it is critical to correct the hyperglycemia slowly. Otherwise, cerebral edema with the disastrous outcome can occur. Similarly, adding fluids while administering insulin in this situation can further aggravate the situation. This usually happens in children and 40% of the patients that develop cerebral edema may end up with severe brain damage.

In this short video, Dr. Mobeen presents the pathophysiological mechanism of the development of effective hypo-osmolality and the development of the cerebral edema if hyperglycemia is rapidly corrected.

Management of DKA:

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. …
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

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15 comments

  1. Julius Fra Fremtiden Mæhlen

    Isnt the correction of diabetic ketoacidosis rather due to idiogenic osmoles produced by neurons in response to the increased osmolarity of the blood due to the lack of insulin? This way quickly altering the osmolarity will cause brain edema, not because of insuline itself as we all know the brain has low levels of Glut 4 compared to other tissues like adipose tissue or skeletal muscle.

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